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Publications
Published papers (includes papers in press)
2024
Maldonado SS, Cedars MI, Yates KP, Wilson
LA, Gill R, Terrault NA, Suzuki A, Sarkar MA.
Anti-Mullerian Hormone, a Marker of Ovarian Reserve,
Is Protective Against Presence and Severity of NASH
in Premenopausal Women.
Clin Gastroenterol Hepatol.
2024 Feb;22(2):339-346.e5.
Epub 2023 Sep 9.
PMC10840970
2023
Gill RM, Allende D, Belt PH, Behling CA, Cummings OW,
Guy CD, Carpenter D, Neuschwander-Tetri BA, Sanyal
AJ, Tonascia J, Van Natta ML, Wilson LA, Yamada G,
Yeh M, Kleiner DE; Nonalcoholic Steatohepatitis
Clinical Research Network (NASH CRN). The
nonalcoholic steatohepatitis extended hepatocyte
ballooning score: histologic classification and
clinical significance. Hepatol Commun. 2023
Feb 1;7(2):e0033.
PMC9894357
Goyal NP, Rosenthal SB, Nasamran C, Behling CA,
Angeles JE, Fishbein MH, Harlow KE, Jain AK,
Molleston JP, Newton KP, Ugalde-Nicalo P, Xanthankos
SA, Yates K, Schork NJ, Fisch KM, Schwimmer JB; NASH
Clinical Research Network. Nonalcoholic fatty liver
disease risk and histologic severity are associated
with genetic polymorphisms in children. Hepatology.
2023 Jan 1;77(1):197-212. Epub 2022 Jun 20.
PMC9653518
Huang DQ, Wilson LA, Behling C, Kleiner DE,
Kowdley KV, Dasarathy S, Amangurbanova M, Terrault
NA, Diehl AM, Chalasani N, Neuschwander-Tetri BA,
Sanyal AJ, Tonascia J, and Loomba R for the NASH
Clinical Research Network. Fibrosis Progression
Rate in Biopsy-proven Nonalcoholic Fatty Liver
Disease among Patients with Diabetes versus Patients
without Diabetes: A Multicenter Study. Gastroenterology. 2023 Aug;165(2):463-472.e5.
Epub 2023 Apr 29.
PMC10699569
Jain AK, Buchannan P, Yates KP, Belt P,
Schwimmer JB, Rosenthal P, Murray KF, Molleston JP,
Scheimann A, Xanthakos SA, Behling CA, Hertel P,
Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos Mb,
for the Nonalcoholic Steatohepatitis Clinical
Research Network.
Nutrition Assessment and MASH Severity in Children
Using the Healthy Eating Index. Hepatol Commun.
2023 Dec 7;7(12):e0320. PMID: 38055641.
Jarasvaraparn C, Vilar-Gomez E, Yates KP,
Wilson LA, Neuschwander-Tetri B, Loomba R, Cummings
O, Vos M, Xanthakos S, Schwimmer J, Molleston JP,
Sanyal A, Tonascia J, Chalasani N. Age,
BMI, and type 2 diabetes modify the relationship
between PNPLA3 and advanced fibrosis in children and
adults with NAFLD. Clin Gastroenterol Hepatol.
2023 Dec 23:S1542-3565(23)01041-8. Epub ahead of print.
PMID: 38145725.
Newton KP, Wilson L, Crimmins NA, Fishbein M,
Molleston J, Xanthakos S, Behling C, Schwimmer JB;
Nonalcoholic Steatohepatitis Clinical Research
Network. Incidence of Type 2 Diabetes in Children With
Nonalcoholic Fatty Liver Disease.
Clin
Gastroenterol Hepatol. 2023 May;21(5):1261-1270. Epub 2022 Jun 13.
PMC10151072
Sanyal AJ, Foucquier J, Younossi ZM, Harrison SA,
Newsome PN, Chan WK, Yilmaz Y, De Ledinghen V,
Costentin C, Zheng MH, Wai-Sun Wong V, Elkhashab M,
Huss RS, Myers RP, Roux M, Labourdette A, Destro M,
Fournier-Poizat C, Miette V, Sandrin L, Boursier J.
Enhanced diagnosis of advanced fibrosis and
cirrhosis in individuals with NAFLD using FibroScan-based
Agile scores. J Hepatol. 2023 Feb;78(2):247-259. Epub
2022 Nov 12.
PMC10170177
Sanyal AJ, Shankar SS, Yates KP, Bolognese J,
Daly E, Dehn C, Neuschwander-Tetri B, Kowdley K,
Vuppalanchi R, Behling C, Tonascia J, Samir A,
Sirlin C, Sherlock SP, Fowler K, Heymann H, Kamphaus
T, Loomba R, Calle RA. Diagnostic performance
of circulating biomarkers for non-alcoholic steatohepatitis.
Nat Med.
2023
Oct;29(10):2656-2664. Epub
2023 Sep 7.
PMC10579051
Sanyal AJ, Williams SA, Lavine JE,
Neuschwander-Tetri BA, Alexander L, Ostroff R,
Biegel H, Kowdley KV, Chalasani N, Dasarathy S,
Diehl AM, Loomba R, Hameed B, Behling C, Kleiner DE,
Karpen SJ, Williams J, Jia Y, Yates KP, Tonascia J.
Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in
non-alcoholic fatty liver disease. J Hepatol.
2023 Apr;78(4):693-703. Epub 2022 Dec 14.
PMC10165617
Shen W, Middleton MS, Cunha GM, Delgado TI, Wolfson
T, Gamst A, Fowler KJ, Alazraki A, Trout AT, Ohliger
MA, Shah SN, Bashir MR, Kleiner DE, Loomba R,
Neuschwander-Tetri BA, Sanyal AJ, Zhou J, Sirlin CB,
Lavine JE. Changes in abdominal adipose tissue
depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis. J Hepatol. 2023 Feb;78(2):238-246.
Epub 2022 Nov 8.
PMC9852022
Vilar-Gomez E, Liang T, Yates K, Wilson L, Loomba R,
Chalasani N. The Protection Conferred by HSD17B13
rs72613567 on Hepatic Fibrosis Is Likely Mediated by
Lowering Ballooning and Portal Inflammation. Clin Gastroenterol Hepatol
2023;21:2981-2983. Epub 2022 Nov 17.
PMC10188654
Wang A, Blackford AL, Behling C, Wilson LA,
Newton KP, Xanthakos SA, Fishbein MH, Vos MB,
Mouzaki M, Molleston JP, Jain AK, Hertel P, Harlow
Adams K, and Schwimmer JB for the NASH CRN.
Development of Fibro-PEN, a Clinical Prediction
Model for Moderate to Severe Fibrosis in Children
with Nonalcoholic Fatty Liver Disease.
Hepatology.
2023 Oct 23. Epub ahead of print. PMID: 37870272.
Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal
P. Shorter Leukocyte Telomere Length Protects
Against NAFLD Progression in Children. Sci Rep.
2023 Apr 3;13(1)5446.
PMC10070244
2022
Brandman D, Boyle
M, McPherson S, Van Natta ML, Sanyal AJ, Kowdley K,
Neuschwander-Tetri B, Chalasani N, Abdelmalek MF,
Terrault NA, McCullough A, Bettencourt R, Caussy C,
Kleiner DE, Behling C, Tonascia J, Anstee QM, Loomba R.
Comparison of clinical prediction rules for detection of
cirrhosis in nonalcoholic fatty liver disease (NAFLD).
Aliment Pharmacol Ther. 2022 Jun;55(11):1441-1451.
Epub 2022 Mar 17.
PMC9098681
Vilar-Gomez E, Pirola CJ, Sookoian S, Wilson LA,
Liang T, Chalasani N. PNPLA3 rs738409 and risk of
fibrosis in NAFLD: Exploring mediation pathways
through intermediate histological features.
Hepatology. 2022 Nov;76(5):1482-1494. Epub
2022 Apr 21.
PMC9519813
Vos MB, Van Natta ML, Blondet NM, Dasarathy
S, Fishbein M, Hertel P, Jain AK, Karpen SJ, Lavine
JE, Mohammad S, Miriel LA, Molleston JP, Mouzaki M,
Sanyal A, Sharkey EP, Schwimmer JB, Tonascia J,
Wilson LA, Xanthakos SA; NASH Clinical Research
Network. Randomized placebo-controlled
trial of losartan for pediatric NAFLD. Hepatology.
2022 Aug;76(2):429-444. Epub 2022 Feb 28.
PMC9288975
Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R,
Cordell HJ, He J, Gindin Y, Chung C, Myers RP,
Schneider CV, Park J, Lee KM, Serper M, Carr RM,
Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X,
Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri
A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy
KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan
J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK,
Krauss RM, Vilarinho S, Brancale J, Nielsen JB,
Locke AE, Jones MB, Verweij N, Baras A, Reddy KR,
Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ,
Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD,
Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven
PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS,
Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer
SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV,
Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA,
Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter
JI, Lynch JA; Regeneron Genetics Center;
Geisinger-Regeneron DiscovEHR Collaboration; EPoS
Consortium; VA Million Veteran Program; Rader DJ,
Voight BF, Chang KM. A multiancestry genome-wide
association study of unexplained chronic ALT
elevation as a proxy for nonalcoholic fatty liver
disease with histological and radiological
validation. Nat Genet. 2022 Jun;54(6):761-771. Epub
2022 Jun 2.
PMC10024253
Woreta TA, Van Natta ML, Lazo M, Krishnan A,
Neuschwander-Tetri BA, Loomba R, Mae Diehl A,
Abdelmalek MF, Chalasani N, Gawrieh S, Dasarathy S,
Vuppalanchi R, Siddiqui MS, Kowdley KV, McCullough
A, Terrault NA, Behling C, Kleiner DE, Fishbein M,
Hertel P, Wilson LA, Mitchell EP, Miriel LA, Clark
JM, Tonascia J, Sanyal AJ; NASH Clinical Research
Network. Validation of the accuracy of the
FAST™ score for detecting patients with at-risk
nonalcoholic steatohepatitis (NASH) in a North
American cohort and comparison to other non-invasive
algorithms. PLoS One. 2022 Apr 15;17(4):e0266859.
eCollection 2022.
PMC9012361
2021
Allende DS, Gawrieh
S, Cummings OW, Belt P, Wilson L, Van Natta M, Behling
CA, Carpenter D, Gill R, Kleiner DE, Yeh MM, Chalasani
N, Guy CD; NASH Clinical Research Network.
Glycogenosis is common in nonalcoholic fatty liver
disease and is independently associated with ballooning,
but lower steatosis and lower fibrosis. Liver Int.
2021 May;41(5):006-1011.
PMC8052274
Gawrieh S, Harlow KE,
Pike F, Yates KP, Wilson LA, Cummings OW, Rosenberg WM,
Chalasani N, Molleston JP.
Relationship of Enhanced Liver Fibrosis Score with Pediatric
Nonalcoholic Fatty Liver Disease Histology and Response to
Vitamin E or Metformin. J Pediatr.
2021 Dec;239:161-167.e5. Epub 2021 Aug 13.
PMC8922020
Gawrieh S,
Wilson
LA, Yates KP, Cummings OW, Vilar-Gomez E, Ajmera V,
Kowdley KV, Rosenberg WM, Tonascia J, Chalasani N.
Relationship of ELF and PIIINP with Liver Histology and
Response to Vitamin E or Pioglitazone in the PIVENS
Trial. Hepatol Commun.
2021 Feb;5(5):786-797. PMC8122381
Newton KP, Lavine JE,
Wilson LA, Behling C, Vos MB, Molleston JP, Rosenthal P,
Miloh T, Fishbein MH, Jain AK, Murray KF, Schwimmer JB,
for the Nonalcoholic Steatohepatitis Clinical
Research
Network (NASH CRN). Alanine aminotransferase and
gamma glutamyl transpeptidase predict histologic
improvement in pediatric nonalcoholic steatohepatitis.
Hepatology.
2021 Mar;73:937-51.
PMC7669708
Sanyal
AJ, Van Natta ML, Clark J, Neuschwander-Tetri BA,
Diehl AM, Dasarathy S, Loomba R, Chalasani N, Kowdley K,
Hameed B, Wilson LA, Yates KP, Belt P, Lazo M, Kleiner DE,
Behling C, Tonascia J for the NASH CRN Clinical Research
Network (CRN). Prospective Study of Outcomes in Adults with
Nonalcoholic Fatty Liver Disease. N Engl J Med.
2021 Oct 21; 385:1559-1569.
PMC8881985
Sarkar
M, Suzuki A, Abdelmalek M, Yates K, Wilson L, Bass NM, Gill R, Cedars M, Terrault N.
Testosterone is Associated With Nonalcoholic Steatohepatitis (NASH) and Fibrosis in Pre-Menopausal Women With NAFLD. Clin Gastroenterol Hepatol.
2021 Jun;19:1267-1274. PMC8175071
Sarkar M, Yates K, Suzuki A, Lavine J, Gill R, Ziegler T, Terrault N, Dhindsa S.
Low testosterone is associated with nonalcoholic steatohepatitis and fibrosis severity in men. Clin Gastroenterol Hepatol.
2021 Feb;19(2):400-402.e2. Epub 2019 Dec 5.
PMC7272262
Vilar-Gomez E, Gawrieh S, Liang T, McIntyre AD, Hegele RA, Chalasani N.
Interrogation of selected genes influencing serum LDL-Cholesterol levels in patients with well characterized NAFLD.
J Clin Lipidol.
2021 Mar-Apr;15(2): 275-91. Epub 2020 Dec 27.
PMC8187295
Vilar-Gomez E, Pirola CJ, Sookoian S, Wilson L, Belt P, Liang T, Liu W, Chalasani N.
Impact of the association between PNPLA3 genetic variation and dietary intake on the risk for significant fibrosis in patients with NAFLD.
Am J Gastroenterol.
2021 May 1;116(5):994-1006.
PMC8087619
Vilar-Gomez E, Pirola CJ, Sookoian S, Wilson LA,
Liang T, Chalasani N. The Protection Conferred by
HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis
and Fibrosis May Be Limited to Selected Subgroups of
Patients With NAFLD. Clin Transl Gastroenterol.
2021 Sep 10;12(9):e00400.
PMC8437218
Yu J, Zhu C, Wang X, Kim K, Bartolome A, Dongiovanni P, Yates KP, Valenti L, Carrer M, Sadowski T, Qiang L, Tabas I, Lavine JE, Pajvani UB.
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Sci Transl Med.
2021 Jun 23;13(599):eabe1692.
PMC8792974
2020
Loomba R, Neuschwander-Tetri BA, Sanyal A, Chalasani N,
Diehl AM, Terrault N, Kowdley K, Dasarathy S, Kleiner D,
Behling C, Lavine J, Van Natta M, Middleton M, Tonascia
J, Sirlin C; NASH Clinical Research Network. Multicenter
Validation of Association Between Decline in MRI-PDFF
and Histologic Response in NASH. Hepatology.
2020 Oct;72(4):1219-1229.
PMC8055244
Mueller NT, Liu T,
Mitchel EB, Yates KP, Suzuki A, Behling C, Lavine JE.
Sex hormone relations to histologic severity of
pediatric nonalcoholic fatty liver disease. J Clin
Endocrinol Metab.
2020 Nov;105(11):3496-504. PMC7494240
Siddiqui MS, Van Natta ML, Connelly MA, Vuppalanchi
R, Neuschwander-Tetri BA, Tonascia J, Guy C, Loomba R,
Dasarathy S, Wattacheril J, Chalasani N, Sanyal AJ, for
the NASH CRN.
Impact of Obeticholic Acid on the Lipoprotein Profile in
Patients with Nonalcoholic Steatohepatitis. J Hepatol.
2020 Jan;72(1):25-33. Epub 2019 Oct 18.
PMC6920569
Vilar-Gomez E, Sookoian S, Pirola CJ, Liang T,
Gawrieh S, Sanyal A, Cummings O, Liu W, Chalasani N.
ADH1B*2 is Associated With Reduced Severity of
Nonalcoholic Fatty Liver Disease in Adults, Independent
of Alcohol Consumption. Gastroenterology. 2020
Sep;159(3):929-943.
Epub 2020 May 23.
PMC7502531
Xanthakos SA, Lavine JE, Yates KP, Schwimmer JB,
Molleston JP, Rosenthal P, Murray KF, Vos MB, Jain AK,
Scheimann AO, Miloh T, Fishbein M, Behling CA, Brunt EM,
Sanyal A, Tonascia J, NASH Clinical Research Network. Progression of fatty liver disease in children receiving standard of care lifestyle advice.
Gastroenterology.
2020 Nov;159:1731-1751.e10. Epub 2020 Jul 23. PMC7680281
2019
Banini BA, Cazanave SC,
Yates KP, Asgharpour A, Vincent R, Mirshahi F, Le P,
Contos MJ, Tonascia J, Chalasani NP, Kowdley KV,
McCullough AJ, Behing CA, Schwimmer JB, Lavine JE, and
Sanyal AJ, for the NASH CRN. Haptoglobin 2 allele is
associated with histological response to vitamin E in
subjects with nonalcoholic steatohepatitis. J Clin
Gastroenterol.
2019 Nov/Dec;53:750-758.
PMC6588507
Bashir MR, Wolfson T,
Gamst AC, Fowler KJ, Ohliger M, Shah SN, Alazraki A,
Trout AT, Behling C, Allende DS, Loomba R, Sanyal A,
Schwimmer J, Lavine JE, Shen W, Tonascia J, Van Natta
ML, Mamidipalli A, Hooker J, Kowdley KV, Middleton MS,
Sirlin CB, on behalf of the NASH Clinical Research
Network (NASH CRN). Hepatic R2* is more strongly
associated with proton density fat fraction than
histologic liver iron scores in patients with
nonalcoholic fatty liver disease. J Magn Reson
Imaging.
2019 May;49:1456–1466. Epub 2018 Oct 4.
PMC6449180
Brunt EM, Kleiner DE,
Wilson LA, Sanyal AJ, Neuschwander-Tetri BA, for the
NASH Clinical Research Network. Improvements in
histologic features and diagnosis are associated with
improvements in fibrosis in NASH: Results from the NASH
Clinical Research Network Treatment Trials. Hepatology.
2019 Aug;70:522-531. Epub 2019 Mar 7.
PMC6570584
Corey KE, Wilson LA,
Altinbas A, Yates KP, Kleiner DE, Chung RT, Krauss RM,
Chalasani N, for the NASH Clinical Research Network.
Relationship between resolution of non-alcoholic
steatohepatitis and changes in lipoprotein
sub-fractions: A post-hoc analysis of the PIVENS trial.
Aliment Pharmacol Ther.
2019 May;49:1205–1213. Epub 2019 Mar 10.
PMC6461513
Gawrieh S, Wilson LA,
Cummings OW, Clark JM, Loomba R, Hameed B, Abdelmalek
MF, Dasarathy S, Neuschwander-Tetri BA, Kowdley K,
Kleiner D, Doo E, Tonascia J, Sanyal A, Chalasani N, for
the NASH Clinical Research Network.
Histologic Findings of Advanced Fibrosis and Cirrhosis
in Patients With Nonalcoholic Fatty Liver Disease Who
Have Normal Aminotransferase Levels. Am J Gastro.
2019 Oct;14:1626-1635.
PMC6800246
Gawrieh S, Guo X, Tan J,
Lauzon M, Taylor KD, Loomba R, Cummings OW, Pillai S,
Bhatnagar P, Kowdley KV, Yates K, Wilson LA, Chen Y-D I,
Rotter JI, Chalasani N; for the NASH Clinical Research
Network. A Pilot Genome-Wide Analysis Study Identifies Loci
Associated with Response to Obeticholic Acid in Patients
with NASH. Hepatol Commun.
2019 Nov;3:1571-1584.
PMC6887685
Kleiner DE, Brunt EM,
Wilson LA, Behling C, Guy C, Contos M, Cummings O, Yeh
M, Gill R, Chalasani N, Neuschwander-Tetri BA, Diehl AM,
Dasarathy S, Terrault N, Kowdley K, Loomba R, Belt P,
Tonascia J, Lavine JE, Sanyal AJ; for the Nonalcoholic
Clinical Research Network.
Association of histologic
disease activity with progression of nonalcoholic fatty
liver disease. JAMA Network Open.
2019 Oct 2;2(10):e1912565.
PMC6784786
Ma Y, Belyaeva OV, Brown PM, Fujita K, Valles K,
Karki S, de Boer YS, Koh C, Chen Y, Du X, Handelman SK,
Chen V, Speliotes EK, Nestlerode C, Thomas E, Kleiner
DE, Zmuda JM, Sanyal AJ; (for the Nonalcoholic
Steatohepatitis Clinical Research Network), Kedishvili
NY, Liang TJ, Rotman Y. 17-Beta Hydroxysteroid
Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase
Associated With Histological Features of Nonalcoholic
Fatty Liver Disease. Hepatology.
2019 Apr;69(4):1504-1519. Epub 2019 Mar 5.
PMC6438737
Schwimmer JB*, Johnson
JS*, Angeles JE, Behling C, Belt PH, Borecki I, Bross C,
Durelle J, Goyal NP, Hamilton G, Holtz ML, Lavine JE,
Mitreva M, Newton KP, Pan A, Simpson PM, Sirlin CB,
Sodergren E, Tyagi R, Yates KP, Weinstock G, Salzman NH.
Microbiome signatures associated with steatohepatitis
and moderate to severe fibrosis in children with
nonalcoholic fatty liver disease. Gastroenterology.
2019 Oct;157:1109-1122. Epub 2019 Jun 27.
PMC6756995
*shared first authorship
Siddiqui MS, Yamada G,
Vuppalanchi R, Van Natta M, Guy C, Brandman D, Tonascia
J, Chalasani N, Neuschwander-Tetri BA, Sanyal AJ, for
the NASH Clinical Research Network. Diagnostic Accuracy of Non-Invasive Fibrosis Models to
Detect Change in Fibrosis Stage.
Clin
Gastroenterol Hepatol.
2019 Aug;17:1877-1885. Epub 2019 Jan 4.
PMC6609497
Siddiqui MS, Vuppalanchi R, Van Natta ML, Hallinan E,
Kowdley KV, Abdelmalek M, Neuschwander-Tetri BA, Loomba
R, Dasarathy S, Brandman D, Doo E, Tonascia J, Kleiner
DE, Chalasani N, Sanyal AJ, for the NASH Clinical
Research Network. Vibration-controlled transient
elastography to assess fibrosis and steatosis in
patients with nonalcoholic fatty liver disease.
Clin
Gastroenterol Hepatol.
2019 Jan;17:156-163.e2. Epub 2018 Apr 26.
PMC6203668
Wang K, Mamidipalli A,
Retson T, Bahrami N, Hasenstab K, Blansit K, Bass E,
Delgado T, Cunha G, Middleton MS, Loomba R,
Neuschwander-Tetri BA, Sirlin CB, Hsiao A, for the NASH
Clinical Research Network.
Automated
CT and MRI liver segmentation and biometry using a
generalized convolutional neural network. Radiology: Artificial
Intelligence.
2019 Mar;1(2):e180022. Epub 2019 Mar 27.
PMC7314107
2018
Africa JA, Behling CA,
Brunt EM, Zhang N, Luo Y, Wells A, Hou J, Belt PH, Kohli
R, Lavine JE, Molleston JP, Newton KP, Whitington PF,
Schwimmer JB, for the Nonalcoholic Steatohepatitis
Clinical Research Network (NASH CRN).
In children
with nonalcoholic fatty liver disease, Zone 1 steatosis
is associated with advanced fibrosis. Clin Gastroenterol Hepatol.
2018 Mar;16:438-446.e1. Epub 2017 Mar 7.
PMC5589478
Ajmera V, Belt P, Wilson
LA, Gill RM, Loomba R, Kleiner DK, Neuschwander-Tetri
BA, Terrault N, for the NASH Clinical Research Network.
Among patients with nonalcoholic fatty liver
disease, modest alcohol use is associated with less
improvement in histologic steatosis and steatohepatitis.
Clin Gastroenterol Hepatol.
2018 Sep;16:1511-1520.e5. Epub 2018 Mar 14.
PMC6098737
Elbel E, Lavine JE,
Downes M, Van Natta M, Yu R, Schwimmer JB, Behling C,
Brunt E, Tonascia J, Evans R.
Hepatic nuclear
expression associates with features of histology in
pediatric nonalcoholic fatty liver disease. Hepatol
Commun.
2018 Sep 27;2:1210-1223. eCollection 2018 Oct.
PMC6167075
Hameed B, Terrault N,
Gill R, Loomba R, Chalasani N, Hoofnagle J, Van Natta M.
Clinical and metabolic effects associated with
weight changes and obeticholic acid in nonalcoholic
steatohepatitis. Aliment Pharmacol Ther.
2018 Mar;47:645-656. Epub 2018 Jan 14.
PMC5931362
Harlow KE, Africa JA, Wells A, Hou J, Belt PH, Behling CA, Jain AK, Molleston JP, Newton KP, Rosenthal P, Vos MB, Xanthakos SA, Lavine JE, Schwimmer JB, for the Nonalcoholic Steatohepatitis Clinical Research Network. Clinically actionable hypercholesterolemia and hypertriglyceridemia in children with nonalcoholic fatty liver disease.
J Pediatr.
2018 Jul;198:76-83.e2. Epub 2018 Apr 13.
PMC6019181
Middleton MS, Van Natta
ML, Heba ER, Alazraki A, Trout AT, Masand P, Brunt EM,
Kleiner DE, Doo E, Tonascia J, Lavine JE, Shen W,
Hamilton G, Schwimmer JB, Sirlin CB, for the NASH
Clinical Research Network.
Diagnostic accuracy of
magnetic resonance imaging hepatic proton density fat
fraction in pediatric nonalcoholic fatty liver disease.
Hepatology.
2018 Mar;67:858-872. Epub 2018 Jan 26.
PMC6211296
Rausch JC, Lavine JE, Chalasani N, Guo X, Kwon S, Schwimmer JB, Molleston JP, Loomba R, Brunt EM, Chen Y-D I, Goodarzi MO, Taylor KD, Yates KP, and Rotter JI, for the NASH Clinical Research Network.
Genetic variants associated with obesity and insulin
resistance in Hispanic boys with nonalcoholic fatty
liver disease. J Pediatr Gastroenterol Nutr.
2018 May;66(5):789-796.
PMC5916321
Vuppalanchi R, Siddiqui
MS, Van Natta ML, Hallinan E, Brandman D, Kowdley K,
Neuschwander-Tetri BA, Loomba R, Dasarathy S, Abdelmalek
M, Doo E, Tonascia J, Kleiner DE, Sanyal AJ, Chalasani
N, for the NASH Clinical Research Network.
Performance characteristics of vibration-controlled
transient elastography for evaluation of nonalcoholic
fatty liver disease. Hepatology.
2018 Jan;67(1):134-44. Epub 2017 Nov 29.
PMC5739967
Wattacheril J, Shea PR,
Mohammad S, Behling C, Aggarwal V, Wilson LA, Yates KP,
Ito J, Fishbein M, Stong N, Lavine JE, Goldstein JB.
Exome sequencing of an adolescent with nonalcoholic
fatty liver disease identifies a clinically actionable
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2009 Oct;7(10):1104-12. Epub 2009 Jun 10.
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2008 Apr;26(3):347-59. Epub 2008 Feb 21.
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2006 Lavine JE, Schwimmer JB. Clinical research network
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2006 Feb;42(2):129-30.
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2005 Kleiner DE, Brunt EM,
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2005 Jun;41(6):1313-21.
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